Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. So I did. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. Started in February and within a couple of weeks ears started twitching. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. This morning was the first morning he left water in his bowl. She has episodes where she seems very anxious and is hiding under car/tables/beds. Been also very lethargic not wanting to get out of bed. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. We did not make the connection until today. Hope your pup is doing better!! It comes as the first choice when prescribing a treatment due to its liver flavor. Our dog has not been given another dose. I sure hope he makes it! About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. I hope this product is no longer sold anywhere. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. Skin issues. With Entyce she is getting her appetite back and seems a little better. Moxidectin stops heartworm . All went well until this morning. Has there been any improvement if so how long after did it take ? She keeps running through the house as though looking for something. Once again peed in my office on Saturday. No diarrhea or vomiting or seizures. Im not sure if the simperica is the cause. The following day he died. I'll continue to watch her. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. The FDA continues to monitor adverse drug event reports for these products and encourages pet owners and veterinarians to report adverse drug events. Itching has decreased immensely. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. My vet prescribed my 16 week old puppy this drug because of a skin irritation. If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Again he has diarrhea and this month he seems agitated or nervous. Overly anxious. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. (toy aussie & corgi). Omg this is horrible. Will not use this again and will warn others. Is there hope? After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. You ask why they are giving this poison to our furbabies, it's easy. Compared to other products, the efficiency of this . Im beside myself with guilt and fear. Took a dose of simparica trio.second rose in second month.dog is having tremors. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. The following list includes the known side effects of Simparica. What is Simparica Trio for dogs? I need to tell my vet to switch! She has NEVER done that before. . She has been the healthiest, happiest dog. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Even when asked to go for a car ride he didn't respond. Our baby isnt the same at all since his one and only dose of Simparica. She seems more anxious now and really attached to hubby. He was a normal dog before the medicine Simpatico Trio . Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. As I read all the comments I am so alarmed. The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. The vet suggested this medication for my 9+ yr old English Bulldog. No more of this poison for him. For: My baby is so sick from this Drug. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. This past October he just wasn't the same. He is also running a fever so is not out of the woods. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. They don't really have an answer for why this happens at all, or why some dogs get better and some don't. A few hours later, he began vomiting nonstop. And my 1 year old cockapoo has been having regular seizures and her blood work has come back indicative of liver dysfunction. Now her dog is very sick and she has to take the dog to the vet every day in the past week. He has been eating the same organic GF food for the past several years. its been 2 weeks .We just had a blood draw done again and they are still high. Was at the doctors 2 days ago for an emergency appointment. He had been on it for 4-5 months . My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! He would come out of it when I shook him, so I didn't think anything of it at the time. Just hoping you can give me something good and tell me your dog recovered. So far, the cost of diagnostic tests are about $700. I hate that I did this to her and I hate that the Vet does not seem to care. Why the vets use this treatment after so many side effects being reported is disgusting. I am so mad at myself and so upset that I am the one that has made him sick. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. Oh Lord, back to finding another vet. I have an 8 year old Labrador. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." So your dog got better? But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. This medicine needs to be stopped. Mine is. Them I took him to a vet for check up and to my horror, he has fleas and a tick. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. Gave Simparica to my dog yesterday. How is your cockapoo doing now? Very "out of it". Thannks !! Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. He has never acted like he was in pain. I have a happy healthy 14 yr old female bull terrier. I just want to cry! Is Simparica only available with a prescription? I would find another vet for a second opinion. I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. Hearing 35-40 to leave systems. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. She went on 2 antibiotics, and medicated baths twice a week. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . So sorry you are having to go through this! The Maltese mix is lethargic and wont jump on bed or couch. I am so sorry to all of you and my heart goes out to you and your babies. He has been low energy since. Omg, this is beyond awful and makes me so worried. Now his tail looks like a rat tail. This is so scary. She walks around as if she is on ice with no control of her back legs. The more we complain the more chance we have of saving other dogs. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? this is how Simparica works on insects who bite your dog. Bentlee trusts me an I let him down on this one. For me, Simparica Trio has made parasite control effective and easyI just give her one chewable tablet each month. I won't sleep until we all get the justice for our babies that don't have voices of their own. I should have kept with my gut feeling about any of these oral meds. We did abx, shampoos changed food. My miniature Dash hound did not pull out. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. Does any one think this could be a reaction to Simparico Trio? Since the weather was turning cold, I stopped giving her the Simparica until spring. Again our dog had a major seizure in January and we searched for a neurologist ear by. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. This time he is having seizures. Simparica is pretty new in England and it seems they are trialling it. What is a good replacement? Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. The simparica pushed his body into an Addison's Crisis - his body was literally shutting down. She is lethargic and doesnt want to eat. It's important for your dog to be tested for heartworm disease before starting Simparica Trio (or any other heartworm prevention) because it will not kill adult heartworms and can actually worsen your dog's condition. My husband said , get dressed were taking him in . Which Type of Dog Fence Is Right For Your Pet? Once she is completely healed I am putting her back on those. She seems to be feeling better but still very concerned of why these levels are still up. Furious that this out there for pets. And yeah he ate today 4 chicken breast and appeared to want it even better. All three drugs are pesticides that work by attacking the nervous system of the fleas and ticks, causing death. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Vet says garlic doesn't work and obviously it didn't because he shaved a little of dogs fur and put it on a paper towels and it was full of fleas.The vet gives me Simpirica-ok fleas are dropping off him like crazy. After being ingested by a dog, sarolaner is distributed throughout the body. That evening after giving it to him he has puked various times. I have a chihuahua/miniature pincher mix dog thats 9 yrs. Im throwing away the remaining 5 pills and going back to a topical medicine. Does this sound familiar to anyone? I tried everything but she just didnt have an appetite for anything. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". We just brought him home from hospital today. Do you think that Simparica could cause excessive licking by my dog. He is pissing a lot and often and drinking a lot of water. Would appreciate any opinion you all may have. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. . CET Enzymatic Oral Hygiene Chews for Dogs. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. My dog was super sick the first months of his life. Did you ever get to the bottom of redness in eyes? Those with Diarrhea symptom, did it look like mucus in their pets stool? If fact it specifically states on the product label "Not for use in humans". Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. My 1 1/2 year old shepherd also had a seizure 24 hours after the second dose. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. And for those who have lost their fur babies I am so sorry for your lost. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. How can it not be the Simparica that did this to my baby when nothing else changed. Sunday, he was lethargic and refused to eat. I am convinced this medicine is HORRIBLE and is causing this. Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. DO NOT give this poison to your pets. We asked our vet, but he ignored the question. I hate pills for me so I struggle giving this to him. Sunday I started watching how much water he was drinking feeling bad that I was restricting him, so I made sure to take him out to pee every few hours. He said it would take care of ticks and Trifexis doesn't. I rescued a dog that had a light case of heartworms. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. I realized he had no control over his body . My 15 yr old doodle wasnt given bravecto because of reviews. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. Don't trust your vet, do your own research. Something I will never know what happened to herIf I knew this would kill her I would never had used it. And she keeps whining. I am trying to remain confident that my poor girl will recover. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. Im worried sick. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. Side effects are uncommon, but may occur in some cases. I was using the garlic tabs for the previous dog because the vet put him on Trifexis and he vomited like crazy. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. The next day Bellas stools were quite soft but still had some structure. 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